STEPdb: Sub-cellular Topologies of E.coli Polypeptides.

Table: Type three secretion proteins (T3SS) in E.coli EPEC (O127:H6) (lee locus)  Export to Excel  Export to HTML  Export to XML  Export to CSV  

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Type three secretion proteins (T3SS) in E.coli EPEC (O127:H6) (lee locus)


Protein ID
(Uniprot)
Protein name
E.coliEPEC
(O127:H6)
Protein
Length
Molecular
weight (kDa)
Post-Translational
Modifications
(PTMs)
Secretion
Mechanism
Effect of
deletion mutation
on secretion
Effect on
pedestal
formation
/virulence
Subcellular
Location
Functional
Domains
(PFAM)
Known Function
Known
Interactions
in Bacterium
pathogenic island
 B7UI23_ECO27
Efa1/LifA
 
365.953
N/A
Sec/T5S
N/A
N/A
N/A
N/A
Multi-domain protein: Glucosyl transferase/YopT-like protease/adhesin? Toxin that specifically inhibits lymphocyte proliferation and interleukin 2 (IL-2), IL-4, and gamma interferon production in response to a variety of stimuli-disruption of intestinal epithelial-barrier function via the modulation of Rho GTPase activities
N/A
IE6
N/A
Lom2
 
 
N/A
Sec/Bam
N/A
N/A
outer membrane protein
N/A
N/A
N/A
PP4
BFPB_ECO27
BfpB
 
58.372
N/A
N/A
N/A
N/A
N/A
N/A
Is absolutely required for pilus biogenesis, and for EPEC localized adherence and autoaggregation. Acts at a step in the BFP biogenic pathway after production and processing of the structural pilus subunit BfpA
N/A
N/A
BFPA_ECO27
BfpA
 
20.27
N/A
Pil
N/A
N/A
N/A
N/A
Major repeating bundle-forming pilus (BFP) subunit. Is required for EPEC localized adherence
N/A
N/A
B7USU3_ECO27
FliD
 
48.496
N/A
Fla
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UR63_ECO27
NleF
189
21.388
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UR62_ECO27
NleH2
303
33.683
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UR60_ECO27
NleA, EspI
440
47.478
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UR56_ECO27
Lom3
 
21.787
N/A
Sec/Bam
N/A
N/A
outer membrane protein
N/A
N/A
PP6
B7UP96_ECO27
FlgK
 
57.844
N/A
Fla
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UP11_ECO27
NleE
168
19.723
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UP10_ECO27 
Efa1/LifA-like
 
298.303
N/A
Sec/T5S
N/A
N/A
N/A
N/A
Multi-domain protein:Glucosyl transferase/YopT-like protease/adhesin? Toxin that specifically inhibits lymphocyte proliferation and interleukin 2 (IL-2), IL-4, and gamma interferon production in response to a variety of stimuli-disruption of intestinal epithelial-barrier function via the modulation of Rho GTPase activities
N/A
IE2
B7UNX6_ECO27
NleD
232
25.951
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UNX4_ECO27
NleC
330
37.226
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UNX3_ECO27
NleB1
326
38.056
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UNX2_ECO27
NleG, NleI
192
20.331
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7ULW8_ECO27
EspJ
217
24.583
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7ULW4_ECO27
NleH1
293
32.482
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7ULW1_ECO27
Lom1
 
21.706
N/A
Sec/Bam
N/A
N/A
outer membrane protein
N/A
N/A
PP2
B7UI41_ECO27
YghJ
 
168.101
N/A
T2S
N/A
N/A
inner membrane
N/A
N/A
N/A
B7UI21_ECO27
NleB2
329
37.627
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UI20_ECO27
EspL
549
62.188
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
B7UI17_ECO27
PagC
 
20.307
N/A
Sec/Bam
N/A
N/A
outer membrane protein
N/A
N/A
IE6
B7UH72_ECO27
EspG2
390
 
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
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